Stress & Sleep – Regulate Cortisol, Restore Circadian Balance

Unwind. Repair. Rebuild from Within.

Calm the body’s stress response and restore healthy sleep architecture with adaptogens that modulate cortisol, promote parasympathetic activity, and protect against neuroendocrine fatigue.

Learn About- The Benefits of Targeted Support For Stress and Sleep

Find targeted support by exploring which natural compounds align with your specific wellness goals. Each benefit section links to curated content and synergistic "Stacks"

The Neurobiology of Stress & Sleep

Chronic stress dysregulates the hypothalamic-pituitary-adrenal (HPA) axis, leading to excessive cortisol secretion, increased sympathetic nervous system activation, and disrupted circadian signalling.

This cascade:

  • Inhibits GABA and melatonin pathways
  • Elevates catecholamines (adrenaline/noradrenaline)
  • Reduces sleep quality and REM depth
  • Impairs neuroplasticity and hippocampal function

To reverse this cycle, therapeutic compounds must:

  • Modulate HPA axis feedback
  • Upregulate parasympathetic nervous system tone
  • Reduce neuroinflammation
  • Improve GABAergic and serotonergic signalling

⚙️ Bioactive Compounds That Balance

Every compound we use has a story backed by thousands of years of tradition and now modern scientific research. Begin your journey by exploring each adaptogen’s unique biological activity and role in human health.

Reishi Mushroom (Ganoderma lucidum)

Mechanistic Action:

  • Contains triterpenes that bind to GABA_A receptors, reducing neural excitability and enhancing sleep onset
  • Downregulates cortisol production and HPA axis overactivation
  • Increases slow-wave sleep (SWS) and promotes parasympathetic tone

Models show Reishi extends non-REM sleep and shortens sleep latency, while human studies associate it with improved mood and reduced sleep disturbance scores.

Clinical Relevance: Reishi improves sleep continuity and overall nervous system recovery, particularly in states of heightened arousal or stress dysregulation.

🪨 Shilajit (Fulvic Acid Complex)

Mechanistic Action:

  • Balances dopamine and serotonin precursors, improving emotional resilience and stress modulation
  • Reduces oxidative stress in the hippocampus and amygdala, key regions for emotional regulation
  • Enhances mitochondrial energy in brain tissue, reducing fatigue-related anxiety

Clinical investigations support its anxiolytic and adaptogenic effects in both physical and psychological stress contexts.

Clinical Relevance: Shilajit supports neuroendocrine adaptation, mood stability, and deeper recovery cycles during rest.

Lion’s Mane Mushroom (Hericium erinaceus

Mechanistic Action:

  • Stimulates NGF (nerve growth factor) production, supporting hippocampal repair under chronic stress
  • Improves REM sleep cycles through indirect serotonin modulation
  • Reduces symptoms of anxiety and depressive behaviours in human and animal models

In a 2010 human trial, Lion’s Mane reduced depression and anxiety scores in menopausal women within 4 weeks of supplementation.

Clinical Relevance: Lion’s Mane assists with cognitive resilience under prolonged stress while enhancing sleep depth and emotional recovery.

Synergistic Stacks-

  • Stacking adaptogenic and neurotrophic agents provides layered support to both structural and metabolic components of cognition.

  • Evening Recovery Stack:

    • Reishi Capsules → Sleep initiation + cortisol reduction
    • Lion’s Mane Liquid → REM support + mood stabilisation
    See The "Evening Recovery Stack" Options 

  • Stress Resilience Stack:

    • Shilajit Resin (AM) → Mood buffer + mitochondrial stability
    • Reishi Capsules (PM) → Adrenal and immune balance
    See the "Stress Resilience Stack" Options 

  • Cognitive Calm Stack:

    • Lion’s Mane Capsules → Emotional regulation + sleep-cognition axis
    • Shilajit Resin → Serotonin and dopaminergic support
    See the "Cognitive Calm Stack" Options 
See All "Sleep and Stress Stack" Options

🧬 Functional Outcomes

  • Mechanism

    • GABA modulation
    • Cortisol regulation
    • NGF + hippocampal recovery
    • Serotonin and dopamine support
    • Mitochondrial homeostasis

  • Functional Outcome

    • Decreased neural excitability
    • Balanced energy and sleep-wake cycles
    • Improved mood and cognitive stability
    • Reduced anxiety and emotional fatigue
    • Enhanced stress resilience + sleep depth

Practitioner’s Insight

“Many supplements sedate, but few restore. Reishi and Lion’s Mane work together to recalibrate both neural tone and structural integrity. Shilajit reinforces the emotional buffer by supporting neurotransmitter balance and mitochondrial restoration.” – Dr. T. Navarre, Integrative Psychoneuroendocrinologist

Deep Science Articles

Go deeper with structured, research-informed articles designed to translate complexity into clarity. All articles are reviewed against peer-reviewed literature and published studies.

  • "What Is Dual Extraction?" → /blogs/what-is-dual-extraction
  • "The Role of Fulvic Acid in Nutrient Transport" → /blogs/fulvic-acid-explained
  • "Stacking Mushrooms for Compound Benefits" → /blogs/how-to-stack
  • "Adaptogens vs. Nootropics" → /blogs/adaptogen-vs-nootropic
  • "How to Take Shilajit: Timing, Pairing & Food Ideas" → /blogs/how-to-take-shilajit

Sleep is Recovery. Calm is Power.

Build nervous system resilience and deeper sleep with adaptogens that help you switch off, repair, and recharge.

 Begin Your Calm Stack →